Toshihiro AKAIKE

AFFILIATION  AND  ADDRESS:  
Frontier Research Center,
Graduate School of Bioscience and Biotechnology,
Tokyo Institute of Technology, 4259 Nagatsuta-cho, 
Midori-ku, Yokohama 226-8501, Japan
　　　
TELPHONE : +81-45-924-5790 (Tokyo Tech)
FAX :       +81-45-924-5815 (Tokyo Tech)     E-mail :  takaike@bio.titech.ac.jp

CAREER HISTORY:
1975.03		Ph.D. Synthetic Chemistry. Graduate School of Engineering, 
The University of Tokyo, Japan	
1975-1980		Research Associate, Dept. of Surgical Science, The Heart Institute of 
Japan, Tokyo Women's Medical College (Presently University)	
1980-1990		Associate Professor, Dept of Material Systems Engineering,Faculty of
Engineering, Tokyo University of Agriculture and Technology	
1989-1995		Project Leader of Akaike Project “High-functional Membrane for Molecular Recognition”, Kanagawa Academy of Sci. & Tech.	
1989, 1996		Visiting Professor of University of Paris XIII (France)	
2000		Visiting Professor of Harbin Medical University (China)	
2000-2003		Professor of Shinshu University Graduate School of Medicine	
1990-2009		Professor of Tokyo Institute of Technology, Graduate School of
Bioscience and Biotechnology, Dept. of Biomolecular  Engineering	
2009-present		Professor of Tokyo Institute of Technology, Frontier Reserch Center & Graduate School of Bioscience and Biotechnology,	

SUMMARY OF PRESENT WORK: 
Tissue Engineering and Regenerative Medicine, Biomedical Polymers (Blood-compatible 
Polymers, Cell-Matrix Engineering for Liver and ES cells), Hybrid Artificial Organs (Liver, Pancreas), Cell Biology (Cytokines, Adhesion Molecules, Apotosis, Extracellular Matrix), Hepatology (Liver Cells Pathology & Physiology), Drug and gene Delivery Systems (Polymers & Apatite Derivatives)

HONORS
Tokyo Tech Award for the Best Teacher (2007)
Fellow, Biomaterials Science and Engineering The International Union of  Societies for Biomaterials Science and Engineering (2004) 
Jorge Heller Journal of Controlled Release/CRS Outstanding Paper Award (1997)
Scientific Achievement Award (1989) The Japanese Society for Biomaterials

MAJOR PUBLICATION:
Yue XS, Murakami Y., Tamai T., Nagaoka M., Cho CS., ItoY., Akaike T., A Fusion Protein N-Cadherin-Fc As An Artificial Extracellular Matrix Surface For Maintenance of Stem Cell Features. Biomaterials 31, 5287-5296, （2010）
M. Nagaoka, H. Ise, I. Harada, U. Koshimizu, A. Maruyama, T. Akaike Embryonic
 Undifferentiated Cells Show Scattering Activity on a Surface Coated With Immobilized E-Cadherin.	J.Cell. Biochem. 103:296-310, (2008)
T. Hoshiba, H. Nagahara, C-S.Cho, Y. Tagawa, T. Akaike	Primary hepatocyte survival on non-integrin-recognizable matrices without the activation of Akt signaling. Biomaterials 28　1093-1104, (2007)
Nagaoka, M., Koshimizu, U., Yuasa, S., Hattori, F., Chen, H., Tanaka, T., Okabe, M., Fukuda, K., and Akaike, T. E-cadherin-coated plates maintain pluripotent ES cells without colony formation. PLoS ONE, 1, e15, (2006).
Chowdhury, E.H., Maruyama, A., Kano, A., Nagaoka, M., Hirose, S., Kunou, M., and Akaike, T. pH-sensing nano-crystals of cabonate apatite: Effects on intracellular delivery and release of DNA for efficient expression into mammalian cells. Gene, 376, 87-94, (2006) 
Kim, S-H., Hoshiba, T., and Akaike T. Hepatocyte behavior on synthetic glycopolymer matrix: inhibitory effect of receptor-ligand binding on hepatocyte spreading. Biomaterials, 25, 1813-1823, (2004）
Ise, H., Nikaido, T., Negishi, N., Sugihara, N., Suzuki, F., Akaike T, and Ikeda, U. 
Effective hepatocyte transplantation using rat hepatocytes with low asialoglycoprotein 
receptor expression. Am. J. Pathol., 165, 501-510, (2004)
Kim, S-H., Kim, J-H., and Akaike,,T. Regulation of cell adhesion signaling by synthetic glycoppolymer matrix in primary cultured hepatocyte. FEBS Lett., 553, 433-439, (2003）
Kim, W.J., Sato, Y., Akaike, T., and Maruyama, A. Cationic comb-type copolymers for  
DNA analysis. Nat. Mater., 2, 815-820, （2003）
Ajioka, I, Akaike, T, and Watanabe, Y. Ethanolamine is a co-mitogenic factor for 
Proliferation of primary hepatocytes. J. Cell. Biochem., 84, 249-263, （2002）

Over 800 publications, 45 patents

ACTIVITIES
The Japanese Society of Regenerative Medicine Director
The Japanese Society of Tissue Engineering Director
The Japanese Society for Biomaterials Vice President, Director
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